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PARIS - Serena Williams lost in the second round of the French Open on Wednesday, her earliest exit at a major tournament since falling in the first round at Roland Garros two years ago.

Williams, the defending French Open champion and a 17-time major winner, lost to Garbine Muguruza of Spain 6-2, 6-2.

The loss came a short time after older sister Venus Williams also was eliminated in the second round. Venus lost to Anna Schmiedlova of Slovakia 2-6, 6-3, 6-4.

The sisters would have met in the third round had they both won.

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